vision of SITraN is to develop an international centre
of excellence for basic through to applied research in
neurodegenerative disease to complement the existing
partnerships of academic research groups, government and
charitable research funding bodies, gene expression
profiling and bioinformatics analysis & modelling of the
biological processes, the pharmaceutical industry and
the health care sector.
SITraN has the potential to
make a major impact on the visibility of
neurodegenerative diseases in the UK, bring new
treatments and new hope to patients and carers in the UK
– together with the wider international community, and
significantly accelerate the pace of therapeutic
development using technologies such as experimental
modelling of disease, gene therapy and stem cell
We have made
important contributions to identifying the complicated
pathobiology of motor neuron injury using gene
expression profiling and to the understanding of the
clinical features and pathology of new genetic variants
of MND including those caused by mutations in CHMP2B
and C9ORF72. We have developed new models of MND
and Parkinson's disease in zebrafish, particularly
useful for drug screening. Click
here to read more about our research discoveries.
The Sheffield Institute for
Translational Neuroscience (SITraN) is an essential
development in the fight against motor neuron disease
and other common neurodegenerative disorders of the
motor system. As yet no single Institution anywhere in
the world has developed the necessary critical mass and
facilities to exploit the potential of modern
neuroscience, the 'post-genome' era, and exciting
developments in biomedical therapeutics with specific
focus on this devastating group of illnesses. Centres of
excellence for neurodegneration research across the
globe have achieved considerable progress, but none are
effectively poised to develop these advances to the
full. The establishment of SITraN in Sheffield offers
the opportunity for a coordinated approach to the
development and clinical trialling of new therapies
based on rational targets of proven preclinical
We have received
orphan drug designation status for one drug (apomorphine-S)
emerging from our drug screening programme and for the
use of gene therapy in the childhood form of MND known
as Spinal Muscular Atrophy (SMA). These are now being
taken forwards to the clinic.
We have conducted two new clinical trials in MND
(lithium and olesoxime); and have devised new ways of
supporting nutrition and respiratory function in MND. We
are continuing to tackle new measures to treat
troublesome symptoms experienced by patients with MND
including cough assist, diaphragm pacing and newly
engineered neck support collars.
Click here to read more
about our clinical studies.
Epic 500 mile cycle in 5 days:
Paul Wilson and his grandson Joshi.
James Wilson will be cycling 500 miles
from Thurso in Scotland where he is currently working as a diver to his home
in Liversedge, West Yorkshire in 5 days to raise funds for SITraN and
research into Motor Neuron Disease (MND).
This fantastic challenge is in memory of James's
dad, Paul Wilson who died from MND in December 2009.
The cycle marathon will start on the 18th
November 2013 and James is aiming to raise £2500 from the cycle ride and
a fundraising evening on his return to West Yorkshire.
James Wilson and his sister Ruth Weavill
fundraising for SITraN.
Donations warmly accepted via James JustGiving
Also you can follow his progress on the following